α-ketoacids supply the essential amino acids and reduce the intake of ammonia nitrogen., There are four common forms, D,L-α-Hydroxymethionine Calcium,α-Ketoleucine Calcium, D,L-α-Ketoisoleucine Calcium, α-Ketovaline Calcium and α-Ketophenylalanine Calcium, they are always work together. Ketone or hydroxyamino acid does not contain amidogen, which can help them utilize the nitrogen from non-essential amino acids to transfer into amino acids. This can reduce the synthesis of urea as well as the accumulation of the uremic toxic products. Ketone or hydroxyamino does not cause the ultrafiltration of remnant nephron, alleviate the renal hyperphosphatemia and secondary hyperparathyroidism and improve the status of renal osteodystrophy.